abstract：:Type 1 Diabetes (T1D) is an autoimmune disease in which insulin producing beta cells of the pancreas are selectively destroyed. Glial Fibrillary Acidic Protein (GFAP) expressed in peri-islet Schwann cells (pSCs) and in the ductal cells of the pancreas is one of the candidate autoantigens for T1D. Immune responses to G...

journal_title：Journal of neuroimmunology

authors： Jayasimhan A,Ellis DP,Ziegler AI,Slattery RM

更新日期：2019-02-15 00:00:00

abstract：:Most of the multiple sclerosis (MS) patients are initially diagnosed with relapsing remitting multiple sclerosis (RRMS). Th17 cells and macrophages have been shown to play critical roles in pathogenesis of MS and initiation of CNS tissue damage. MiR-301a have recently been exposed as an activator of STAT3 in Th17 cell...

journal_title：Journal of neuroimmunology

authors： Tavakolpour V,Shokri G,Naser Moghadasi A,Mozafari Nahavandi P,Hashemi M,Kouhkan F

更新日期：2018-12-15 00:00:00

abstract：:Dark-Agouti rats were immunized with spinal cord homogenate to develop Experimental Autoimmune Encephalomyelitis, a model of multiple sclerosis. We assessed motor signs and recorded VEPs for five or eight weeks with epidural or epidermal electrodes, respectively, with final histopathology of optic nerves (ONs). Inject...

journal_title：Journal of neuroimmunology

authors： Castoldi V,Marenna S,Santangelo R,d'Isa R,Cursi M,Chaabane L,Quattrini A,Comi G,Leocani L

更新日期：2018-12-15 00:00:00

abstract：PURPOSE:It will provide a reference for early detection, early diagnosis and early treatment of atypical primary Sjogren syndrome with neurological impairment as the first symptom. METHODS:Case report and Literature review. RESULTS:Here we report a 30-year-old woman diagnosed with trigeminal damage secondary to pSS w...

journal_title：Journal of neuroimmunology

authors： Yuan J,Gong L,Wu H,Chen Q,Wang J,Chen W,Wang X,Ren C

更新日期：2018-11-15 00:00:00

abstract：:Brain capillary endothelial cells are the component of blood brain barrier, and the first line of defense against viruses invading into brain. We demonstrate that treatment of hCMEC/D3 cells, a human brain capillary endothelial cell line, with a Toll-like receptor 3 (TLR3) agonist polyinosinic-polycytidylic acid (poly...

journal_title：Journal of neuroimmunology

authors： Imaizumi T,Sassa N,Kawaguchi S,Matsumiya T,Yoshida H,Seya K,Shiratori T,Hirono K,Tanaka H

更新日期：2018-11-15 00:00:00

abstract：:Clinical and experimental observations emphasize that inflammation is a direct risk factor for stroke. We performed a detailed histological and immunohistochemical analysis, assisted by digital morphometry, to compare the representative brain lesions in the ischemic core and penumbra in a rat model. Focal neuronal nec...

journal_title：Journal of neuroimmunology

authors： Horváth E,Huțanu A,Chiriac L,Dobreanu M,Orădan A,Nagy EE

更新日期：2018-11-15 00:00:00

abstract：:Autoreactive, myelin-specific, CD4+ T cells have a central role in multiple sclerosis (MS) pathogenesis; however the exact phenotype characteristics of these cells remain elusive. Recently, granulocyte-macrophage colony-stimulating factor (GM-CSF) expression has emerged as the main pathological signature of the enceph...

journal_title：Journal of neuroimmunology

authors： Kostic M,Zivkovic N,Cvetanovic A,Stojanovic I

更新日期：2018-10-15 00:00:00

abstract：:Sulfatide is a major glycosphingolipid in myelin and a target for autoantibodies in autoimmune neuropathies. However neuropathy disease models have not been widely established, in part because currently available monoclonal antibodies to sulfatide may not represent the diversity of anti-sulfatide antibody binding patt...

journal_title：Journal of neuroimmunology

authors： Meehan GR,McGonigal R,Cunningham ME,Wang Y,Barrie JA,Halstead SK,Gourlay D,Yao D,Willison HJ

更新日期：2018-10-15 00:00:00

abstract：:Activation states of immune cells (among them, the so-called pro- or anti-inflammatory states) influence the pathogenesis of multiple sclerosis (MS). The neuropeptide calcitonin gene-related peptide (CGRP) can exert a pro- or anti-inflammatory role in a context-dependent manner. In mice CGRP was found to attenuate the...

journal_title：Journal of neuroimmunology

authors： Rossetti I,Zambusi L,Finardi A,Bodini A,Provini L,Furlan R,Morara S

更新日期：2018-10-15 00:00:00

abstract：:Macrophage migration inhibitory factor (MIF) is a cytokine with pleiotropic actions involved in the pathogenesis of autoimmune disorders, including Multiple Sclerosis (MS). We have first evaluated in silico the involvement of MIF, its homologue D-DT, and the receptors CD74, CD44, CXCR2 and CXCR4 in encephalitogenic T ...

journal_title：Journal of neuroimmunology

authors： Fagone P,Mazzon E,Cavalli E,Bramanti A,Petralia MC,Mangano K,Al-Abed Y,Bramati P,Nicoletti F

更新日期：2018-09-15 00:00:00

abstract：:The presence of pre-existing natural antibodies against Alzheimer's disease (AD) pathological proteins might interfere with immune responses to therapeutic vaccination with these proteins. We aimed to compare levels of antibodies in CSF and serum: We observed higher reactivity of natural tau-reactive antibodies toward...

journal_title：Journal of neuroimmunology

authors： Krestova M,Ricny J,Bartos A

更新日期：2018-09-15 00:00:00

abstract：:Primary angiitis of the central nervous system (PACNS) is a rare and heterogeneous inflammatory disease of the CNS vasculature with poorly understood pathophysiology. Comprehensive immune-cell phenotyping revealed increased frequencies of leukocytes in the cerebrospinal fluid (CSF) of PACNS patients compared to patien...

journal_title：Journal of neuroimmunology

authors： Strunk D,Schulte-Mecklenbeck A,Golombeck KS,Meyer Zu Hörste G,Melzer N,Beuker C,Schmidt A,Wiendl H,Meuth SG,Gross CC,Minnerup J

更新日期：2018-08-15 00:00:00

abstract：:We tested the performance of MRZ-reaction, an intrathecal humoral immune response against-Measles (M), Rubella (R) and Varicella Zoster (Z) viruses, in multiple sclerosis (MS) diagnosis. The MRZ-reaction was significantly more positive in MS than in non-MS group with a specificity of 91.9%. In MS group, the RZ-profile...

journal_title：Journal of neuroimmunology

authors： Feki S,Gargouri S,Mejdoub S,Dammak M,Hachicha H,Hadiji O,Feki L,Hammami A,Mhiri C,Karray H,Masmoudi H

更新日期：2018-08-15 00:00:00

abstract：:In 208 children with opsoclonus-myoclonus syndrome (OMS), CSF IgG oligoclonal bands (OCB) and 22 immunomarkers in CSF and 21 in serum/blood were measured. In 36 untreated OMS, 58% were OCB(+), whereas 55% of treated OMS were OCB(-). OCB positivity or negativity did not alter concentrations or frequencies of immunomark...

journal_title：Journal of neuroimmunology

authors： Pranzatelli MR,McGee NR,Tate ED

更新日期：2018-08-15 00:00:00

abstract：:The prevalence of vascular dementia is increasing at an alarming rate. The Confirmation of the clinical diagnosis of vascular dementia depends on post-mortem examination of the brain. In our study, we investigated the vascular disease and neuroinflammation during vascular dementia. Our results showed a β-amyloid depos...

journal_title：Journal of neuroimmunology

authors： Belkhelfa M,Beder N,Mouhoub D,Amri M,Hayet R,Tighilt N,Bakheti S,Laimouche S,Azzouz D,Belhadj R,Touil-Boukoffa C

更新日期：2018-07-15 00:00:00

abstract：:Macrophage migration inhibitory factor (MIF) is a cytokine associated with tissue damage in multiple autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis and psoriatic arthritis. The role of MIF in multiple sclerosis (MS) and the contribution of its polymorphisms are unknown in our population...

journal_title：Journal of neuroimmunology

authors： Castañeda-Moreno VA,De la Cruz-Mosso U,Torres-Carrillo N,Macías-Islas MA,Padilla-De la Torre O,Mireles-Ramírez MA,González-Pérez O,Ruiz-Sandoval JL,Huerta M,Trujillo X,Ortuño-Sahagún D,Muñoz-Valle JF

更新日期：2018-07-15 00:00:00

abstract：:The NF-κB signalling pathway plays an important role in controlling cellular immune responses, inflammation and apoptosis. In multiple sclerosis (MS), there is evidence of dysregulation of NF-κB signalling in patients with a relapsing-remitting disease course, but thus far there is little information on whether it is ...

journal_title：Journal of neuroimmunology

authors： Yan J,Winterford CM,Catts VS,Pat BK,Pender MP,McCombe PA,Greer JM

更新日期：2018-07-15 00:00:00

abstract：:Tissue cysts, the hallmark of chronic Toxoplasma gondii infection, are predominantly located in the brain making clearance of the parasite difficult. Currently available anti-T. gondii drugs are ineffective on cysts and fail to prevent reactivation of latent toxoplasmosis. We examined whether abrogation of inhibitory ...

journal_title：Journal of neuroimmunology

authors： Xiao J,Li Y,Yolken RH,Viscidi RP

更新日期：2018-06-15 00:00:00

abstract：:Epstein-Barr virus (EBV) is the main environmental agent associated to neuromyelitis optica spectrum disorder (NMOSD). Following to studies reporting an increased prevalence of antibodies against peptides derived from Mycobacterium avium subsp. paratuberculosis (MAP) homologous to EBV and human epitopes (MBP85-98, IRF...

journal_title：Journal of neuroimmunology

authors： Bo M,Niegowska M,Arru G,Sechi E,Mariotto S,Mancinelli C,Farinazzo A,Alberti D,Gajofatto A,Ferrari S,Capra R,Monaco S,Sechi G,Sechi LA

更新日期：2018-05-15 00:00:00

abstract：:Longitudinal brain atrophy quantification is a critical efficacy measurement in multiple sclerosis (MS) clinical trials and the determination of No Evidence of Disease Activity (NEDA). Utilising fingolimod as a clinically validated therapy we evaluated the use of repeated brain tissue volume measures during chronic ex...

journal_title：Journal of neuroimmunology

authors： Smith PA,Schmid C,Zurbruegg S,Jivkov M,Doelemeyer A,Theil D,Dubost V,Beckmann N

更新日期：2018-05-15 00:00:00

abstract：:Neurotuberculosis is one of the commonest HIV-associated opportunistic infections (OI) of the CNS. Cross-talk between HIV, Mycobacterium tuberculosis and host immune responses may alter expression of pattern recognition receptors (PRRs), thereby affecting cytokine profiles and functional responses. We examined PRR mRN...

journal_title：Journal of neuroimmunology

authors： Rao D,Vasanthapuram R,Satishchandra P,Desai A

更新日期：2018-05-15 00:00:00

abstract：:To determine clinical features of neurologic disorders associated with anti-glutamic acid decarboxylase antibodies (anti-GAD-Ab), we examined titers and time-dependent changes of anti-GAD-Ab. Six patients, stiff person syndrome (2), cerebellar ataxia (1), limbic encephalitis (1), epilepsy (1), brainstem encephalitis (...

journal_title：Journal of neuroimmunology

authors： Nakajima H,Nakamura Y,Inaba Y,Tsutsumi C,Unoda K,Hosokawa T,Kimura F,Hanafusa T,Date M,Kitaoka H

更新日期：2018-04-15 00:00:00

abstract：:Rituximab has been effectively used for treating neuromyelitis optica spectrum disorder (NMOSD) for several years. However those regimens exert a heavy burden on Chinese patients. The aim of our study was to investigate an effectiveness, economic alternatives of RTX. The enrolled patients received different immunosupp...

journal_title：Journal of neuroimmunology

authors： Lin J,Li X,Xue B,Tong Q,Chen Z,Zhu W,Li J,Xia J

更新日期：2018-04-15 00:00:00

abstract：:Microglial activation is the most common phenomenon in S. aureus induced brain abscesses as well as other common neurodegenerative diseases. The main objective of this study is to reduce the microglial inflammation with effective bacterial elimination. Ciprofloxacin and celecoxib were used in combination to regulate S...

journal_title：Journal of neuroimmunology

authors： Dey R,Sultana S,Bishayi B

更新日期：2018-03-15 00:00:00

abstract：BACKGROUND:Postpartum is a period of unique psychosocial stress characterized by sleep disturbance, risk for depressed mood, and heightened parenting stress. However, data on effects of these exposures on inflammatory immune function are limited. METHODS:This study examined associations among sleep, psychosocial stres...

journal_title：Journal of neuroimmunology

authors： Christian LM,Kowalsky JM,Mitchell AM,Porter K

更新日期：2018-03-15 00:00:00

abstract：:In the last decade, understanding of cancer initiation and progression has been given much attention with studies mainly focusing on genetic abnormalities. Importantly, cancer cells can influence their microenvironment and bi-directionally communicate with other systems such as the immune system. The nervous system pl...

journal_title：Journal of neuroimmunology

authors： Kuol N,Stojanovska L,Apostolopoulos V,Nurgali K

更新日期：2018-02-15 00:00:00

abstract：:Depending on the duration and severity, psychological tension and physical stress can enhance or suppress the immune system in both humans and animals. Although it has been established that chronic stress exerts a significant suppressive effect on immune function, the mechanisms by which affects immune responses remai...

journal_title：Journal of neuroimmunology

authors： Zhang H,Caudle Y,Wheeler C,Zhou Y,Stuart C,Yao B,Yin D

更新日期：2018-01-15 00:00:00

abstract：:Disturbances in Tryptophan metabolism play a crucial role in multiple sclerosis (MS). Exercise is suspected to counteract the progress of MS and its side effects. Current research suggests alterations of Tryptophan metabolism in healthy individuals in response to exercise. We investigated the influence of acute aerobi...

journal_title：Journal of neuroimmunology

authors： Bansi J,Koliamitra C,Bloch W,Joisten N,Schenk A,Watson M,Kool J,Langdon D,Dalgas U,Kesselring J,Zimmer P

更新日期：2018-01-15 00:00:00

abstract：:We compared the retinal thickness in the unaffected eyes among the following subtypes of unilateral optic neuritis (ON): multiple sclerosis (MS-ON), neuromyelitis optica spectrum disorder with anti-AQP4 autoantibody (AQP4-ON), patients with serum anti-MOG antibody (MOG-ON), and idiopathic ON. In the chronic phase, mac...

journal_title：Journal of neuroimmunology

authors： Akaishi T,Kaneko K,Himori N,Takeshita T,Takahashi T,Nakazawa T,Aoki M,Nakashima I

更新日期：2017-12-15 00:00:00

abstract：:The aggregation and deposition of transactivation response DNA-binding protein 43 (TDP-43) in neurons and astrocytes is characteristic in a number of neurodegenerative diseases including Alzheimer's disease, frontotemporal lobar degeneration, and amyotrophic lateral sclerosis. Nevertheless, the exact role of TDP-43 in...

journal_title：Journal of neuroimmunology

authors： Huang CY,Lee YC,Li PC,Liliang PC,Lu K,Wang KW,Chang LC,Shiu LY,Chen MF,Sun YT,Wang HK

更新日期：2017-12-15 00:00:00

abstract：:Cyclophilins have diverse functions that may affect the course of central nervous system (CNS) inflammatory disorders. Anti-inflammatory and neuroprotective mechanisms may be targeted by inhibition of cyclophilin A-dependent and cyclophilin D-dependent functions, respectively. We tested the effect of cyclophilin inhib...

journal_title：Journal of neuroimmunology

authors： Huang ZL,Pandya D,Banta DK,Ansari MS,Oh U

更新日期：2017-10-15 00:00:00

abstract：:The role of cell surface tyrosine kinase collagen-activated receptors known as discoidin domain receptors (DDRs) is unknown in neurodegenerative diseases. We detect up-regulation in DDRs level in post-mortem Alzheimer and Parkinson brains. Lentiviral shRNA knockdown of DDR1 and DDR2 reduces the levels of α-synuclein, ...

journal_title：Journal of neuroimmunology

authors： Hebron M,Peyton M,Liu X,Gao X,Wang R,Lonskaya I,Moussa CE

更新日期：2017-10-15 00:00:00

abstract：:Multiple sclerosis (MS) is a highly prevalent demyelinating disorder, presumed to be driven by an autoimmune response toward the central nervous system (CNS) components. All currently available treatments modulate the immune system globally and besides the reduction of disease activity, they may also impose considerab...

journal_title：Journal of neuroimmunology

authors： Wildner P,Selmaj KW

更新日期：2017-10-15 00:00:00

abstract：:Acute flaccid paralysis is a neuromuscular emergency characterized by rapidly worsening weakness that evolves quickly to cause diaphragmatic failure. The challenge for the treating physician is to stabilize the patient, generate the differential diagnosis and determine the management; all in quick time. Neurotoxic sna...

journal_title：Journal of neuroimmunology

authors： Sundar K,Venkatasubramanian S,Shanmugam S,Arthur P,Subbaraya R,Hazeena P

更新日期：2017-10-15 00:00:00

abstract：OBJECTIVE:The role of fatty acid-binding proteins (FABPs) in atherosclerosis has been investigated. The aim of this study was to verify the hypothesis that higher levels of serum FABP4 could be a biomarker for stroke and associated with stroke severity in Chinese patients with ischemic stroke. METHODS:All consecutive ...

journal_title：Journal of neuroimmunology

authors： Chang L,Zhang J,Liu L,Huang Z,Han Y,Zhu Y

更新日期：2017-10-15 00:00:00

abstract：:We examined anti-complement C1q (C1q) autoantibody levels in serum and cerebrospinal fluid (CSF) samples of patients with neuromyelitis optica spectrum disorders (NMOSD). We analyzed the correlations between anti-C1q autoantibody levels and the clinical and other CSF characteristics of NMOSD. Serum and CSF anti-C1q au...

journal_title：Journal of neuroimmunology

authors： Yoshikura N,Kimura A,Hayashi Y,Inuzuka T

更新日期：2017-09-15 00:00:00

abstract：:We characterized naïve, central memory (CM), effector memory (EM) and terminally differentiated effector memory (TEMRA) CD4+ and CD8+ T cells and their expression of CD49d and CD26 in peripheral blood in patients with multiple sclerosis (MS) and healthy controls. CD26+ CD28+ CD4+ TEMRA T cells were increased in all su...

journal_title：Journal of neuroimmunology

authors： Nielsen BR,Ratzer R,Börnsen L,von Essen MR,Christensen JR,Sellebjerg F

更新日期：2017-09-15 00:00:00

abstract：:Postpartum psychosis (PP) is associated with significant morbidity to both mother and infant. Immune system dysregulation during PP is reported in recent studies. This study attempted to determine immune signatures associated with first-onset PP by flow cytometry. Peripheral blood showed decreased naive CD4 and CD8 T ...

journal_title：Journal of neuroimmunology

authors： Kumar MM,Venkataswamy MM,Sathyanarayanan G,Thippeswamy H,Chandra PS,Mani RS

更新日期：2017-09-15 00:00:00

abstract：:HLA-DR, Iba1 and CD68 are widely used microglia markers in human tissue. However, due to differences in gene regulation, they may identify different activation stages of microglia. Here, we directly compared the expression of HLA-DR, Iba1 and CD68 in microglia with different phenotypes, ranging from ramified to amoebo...

journal_title：Journal of neuroimmunology

authors： Hendrickx DAE,van Eden CG,Schuurman KG,Hamann J,Huitinga I

更新日期：2017-08-15 00:00:00

abstract：:A rare case of neuromyelitis optica spectrum disorder, suspected to be bacterial meningomyelitis as the initial manifestation, is reported. The patient presented with initial symptoms of meningomyelitis and fever. Cerebrospinal fluid analysis revealed pleocytosis (1280×106/L [98% lymphocytes]) and glucose level of 1.8...

journal_title：Journal of neuroimmunology

authors： Li X,Lin J,Pan S,Weng Y,Li J,Zhang X,Xia J,Tong Q

更新日期：2017-08-15 00:00:00